Protein tyrosine phosphatases: structure-function relationships
نویسندگان
چکیده
منابع مشابه
Structure, regulation, and function of protein tyrosine phosphatases.
service Email alerting click here the box at the top right corner of the article or Receive free email alerts when new articles cite this article-sign up in
متن کاملVoltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research
The transmembrane protein Ci-VSP from the ascidian Ciona intestinalis was described as first member of a fascinating family of enzymes, the voltage sensitive phosphatases (VSPs). Ci-VSP and its voltage-activated homologs from other species are stimulated by positive membrane potentials and dephosphorylate the head groups of negatively charged phosphoinositide phosphates (PIPs). In doing so, VSP...
متن کاملProtein tyrosine phosphatases.
The molecular mechanisms of signal transduction have been at the focus of increasingly intense scientific research. As a result, our understanding of protein tyrosine kinase-mediated signaling has advanced at an unprecedented pace during the past decade. In contrast, the study of protein tyrosine phosphatases has lagged behind, but is now gathering momentum and is predicted to become a "hot top...
متن کاملFrom Form to Function: Signaling by Protein Tyrosine Phosphatases
modulate signal transduction events that converge on Tyrosine phosphorylation, controlled by thecoordinated common downstream targets. These observations supactions of protein tyrosine phosphatases (PTPs) and port a critical role for RPTPs in regulating the adhesive kinases (PTKs), is a critical control mechanism for nuevents that control axonal pathfinding. Tyrosine phosmerous physiological pr...
متن کاملProtein-tyrosine phosphatases in development
One of the most important mechanisms of eukaryotic signalling is protein phosphorylation on tyrosine residues, which plays a pivotal role in development by regulating cell proliferation, differentiation and migration. Cellular phosphotyrosine (P.Tyr) levels are regulated by the antagonistic activities of the protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs). We have good ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Journal
سال: 2008
ISSN: 1742-464X
DOI: 10.1111/j.1742-4658.2008.06251.x